Innovative partnership between Florida Hospital and Sanford-Burnham Medical Research Institute will bridge research and treatment to accelerate personalized medicine in diabetes and obesity. ..
Read More ⇒The development of melanoma involves a complex interplay between environmental factors and alterations in gene expression (the way genes are turned on or off). While exposure to UV radiation is a key risk factor for melanoma development, it’s unclear how UV radiation influences which genes are turned on or off in skin cells—a process known as gene expression. This is exactly the question that interests Ranjan J. Perera, Ph.D., scientific director of Analytical Genomics and Bioinformatics and associate professor in the Diabetes and Obesity Research Center at Sanford-Burnham in Lake Nona, Orlando. ..
Read More ⇒Discoveries made in the laboratories of Sanford-Burnham Medical Research Institute at Lake Nona will, for the first time, advance to the clinical research stage involving human studies at the Florida Hospital – Sanford-Burnham Translational Research Institute for Metabolism and Diabetes (TRI). The research will focus on orexin, an appetite-inducing hormone produced in the brain, which appears to resolve obesity without changes in food consumption or elevation in physical activity. ..
Read More ⇒Sanford-Burnham Medical Research Institute (Sanford-Burnham) and Florida Hospital researchers recently returned from Japan where they reviewed the progress that has been made at the mid-point of their research partnership with Takeda Pharmaceutical Company Limited (Takeda). The two-year collaboration focuses on the discovery and evaluation of new therapeutic approaches to obesity. The scientists reported benchmark data that sets the stage for a key element in future drug development–the testing of obesity drug candidates. ..
Read More ⇒Moffitt Cancer Center, Sanford-Burnham Medical Research Institute and Florida Hospital have announced they will collaborate on the creation of a Personalized Medicine Partnership of Florida (PMP Florida). The partnership will conduct collaborative research to accelerate discovery and develop new treatments in the areas of cancer and metabolic diseases, including obesity, diabetes and cardiovascular disease. ..
Read More ⇒Taste receptors on the tongue help us distinguish between safe food and food that’s spoiled or toxic. But taste receptors are now being found in other organs, too. In a study published online February 6 by the Proceedings of the National Academy of Sciences, Sanford-Burnham researchers discovered that beta cells in the pancreas use taste receptors to sense fructose, a type of sugar. According to the study, the beta cells respond to fructose by secreting insulin, a hormone that regulates the body’s response to dietary sugar. ..
Read More ⇒A study published in the Journal of the American Medical Association (JAMA) examines the impact of diets containing varying amounts of protein on weight gain, body composition and energy expenditure. The research, led by Steven R. Smith, M.D., Florida Hospital - Sanford-Burnham Translational Research Institute, and George Bray, M.D., Pennington Biomedical Research Center, found that total calories account for increases in body fat, while increasing the percent of dietary protein during overfeeding led to more lean body mass storage. The research appears to be the first to analyze the impact of dietary protein during overfeeding and provides guidance on dietary composition for healthy weight gain. ..
Read More ⇒Eating a diet higher in protein may help you pack on a better kind of pounds, according to a new study out today in the Journal of the American Medical Association. The study, co-authored by Dr. Steve Smith, scientific director of Florida Hospital-Sanford Burnham Translational Research Institute for Metabolism and Diabetes, examined the effect of diets containing varying amounts of protein on weight gain and body composition. ..
Read More ⇒Layton Smith, Ph.D., assistant professor and director of drug discovery at Sanford-Burnham Medical Research Institute’s Florida campus, has been awarded a Novo Nordisk Diabetes Innovation Award, valued at $477,500 over two years. The grant will further his research into a novel protein with the potential to improve the understanding of diabetes and further the development of new treatments. ..
Read More ⇒Muscle performance and fitness are partly determined by how well your muscle cells use sugar as a fuel source. In turn, exercising improves the muscle’s ability to take up sugars from the bloodstream and burn them for energy. On the flip side, conditions that reduce physical activity—such as obesity or chronic disease—reduce the muscle’s capacity to burn sugar. Sanford-Burnham scientists are now unraveling a mechanism that re-programs metabolic genes in muscles in a way that increases their capacity to use sugar. When activated in mice, this metabolic re-programming dramatically improves exercise performance. ..
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