Thursday, November 23, 2017
SBP Scientists Find Key to Regenerating Blood Vessels

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels.  ..

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Tuesday, September 19, 2017
SBP: How tumors trick immune cells

The aggressiveness of a tumor is determined partly by the properties of the actual cancer cells, but also to a surprisingly large degree by the surrounding environment in which the tumor grows, including blood vessels, fat cells, fibroblasts and immune cells.  ..

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Friday, August 25, 2017
SBP: Heart Hormones Protect Against Obesity and Insulin Resistance

Elevated levels of natriuretic peptides in adipose tissue protect against effects of high-fat diet  ..

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Tuesday, August 08, 2017
Sanford Burnham Prebys and Mayo Clinic Collaborators Awarded Multi-Year NIH Grant

A team of researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona, Fla. and Mayo Clinic in Rochester, Minnesota have been awarded a three-year National Institutes of Health (NIH) grant which aims to identify molecules that could become new medicines to inhibit myocardial fibrosis.  ..

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Monday, July 03, 2017
SBP: Fatty liver disease target of cutting-edge genetic research

In his lab in Lake Nona, Dr. Peter Crawford has been studying nonalcoholic fatty liver disease, a condition that’s closely linked to obesity and type 2 diabetes. He is using cutting edge metabolic and genetic tools to try to figure out how and why nonalcoholic fatty liver disease, or “fatty liver,” progresses into a more severe form, putting the patients at a higher risk of developing cirrhosis and liver cancer.  ..

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Monday, May 15, 2017
Mysterious Molecule’s Function in Skin Cancer Identified

New research from SBP at Lake Nona uncovers the modus operandi of a mysterious molecule called SPRIGHTLY that has been previously implicated in colorectal cancer, breast cancer, and melanoma. The findings, published in the journal Science Advances, bolster the case for exploring SPRIGHTLY as a potential therapeutic target, or a biological marker that identifies cancer or predicts disease prognosis.  ..

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Saturday, March 04, 2017
SBP: Study uses human volunteers to explore link between sugar receptors in the gut and metabolism

Regularly consuming artificial sweeteners increases the chance that you will gain weight and develop type 2 diabetes, but it’s not clear yet whether saccharin, aspartame, and other non-caloric sweeteners directly alter metabolism. If they do, figuring out the molecular basis for their effects could lead to new ways to treat obesity and prevent metabolic problems.  ..

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Wednesday, February 01, 2017
SBP: Does cold weather promote weight loss?

Winter brings cold. Muthu Periasamy, Ph.D., professor at Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona, studies how muscle burns calories to generate heat and keep our bodies warm.  ..

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Wednesday, December 21, 2016
SBP: Incretin drugs may act via more brain pathways than previously thought

GLP-1 agonists (GLP-1RAs) may impact the brain in entirely different ways than was previously thought to promote weight loss. Scientists initially believed that these incretin-based type 2 diabetes drugs only bind to receptors in the hypothalamus but they may in fact affect many more brain circuits. ..

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Friday, November 11, 2016
SBP: How the immune system helps build muscle

Discovery of factor that enhances muscle repair could lead to new therapies for muscle damage ..

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