Friday, August 25, 2017
SBP: Heart Hormones Protect Against Obesity and Insulin Resistance

Elevated levels of natriuretic peptides in adipose tissue protect against effects of high-fat diet  ..

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Tuesday, August 08, 2017
Sanford Burnham Prebys and Mayo Clinic Collaborators Awarded Multi-Year NIH Grant

A team of researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona, Fla. and Mayo Clinic in Rochester, Minnesota have been awarded a three-year National Institutes of Health (NIH) grant which aims to identify molecules that could become new medicines to inhibit myocardial fibrosis.  ..

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Monday, July 03, 2017
SBP: Fatty liver disease target of cutting-edge genetic research

In his lab in Lake Nona, Dr. Peter Crawford has been studying nonalcoholic fatty liver disease, a condition that’s closely linked to obesity and type 2 diabetes. He is using cutting edge metabolic and genetic tools to try to figure out how and why nonalcoholic fatty liver disease, or “fatty liver,” progresses into a more severe form, putting the patients at a higher risk of developing cirrhosis and liver cancer.  ..

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Monday, May 15, 2017
Mysterious Molecule’s Function in Skin Cancer Identified

New research from SBP at Lake Nona uncovers the modus operandi of a mysterious molecule called SPRIGHTLY that has been previously implicated in colorectal cancer, breast cancer, and melanoma. The findings, published in the journal Science Advances, bolster the case for exploring SPRIGHTLY as a potential therapeutic target, or a biological marker that identifies cancer or predicts disease prognosis.  ..

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Saturday, March 04, 2017
SBP: Study uses human volunteers to explore link between sugar receptors in the gut and metabolism

Regularly consuming artificial sweeteners increases the chance that you will gain weight and develop type 2 diabetes, but it’s not clear yet whether saccharin, aspartame, and other non-caloric sweeteners directly alter metabolism. If they do, figuring out the molecular basis for their effects could lead to new ways to treat obesity and prevent metabolic problems.  ..

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Wednesday, February 01, 2017
SBP: Does cold weather promote weight loss?

Winter brings cold. Muthu Periasamy, Ph.D., professor at Sanford Burnham Prebys Medical Discovery Institute (SBP) at Lake Nona, studies how muscle burns calories to generate heat and keep our bodies warm.  ..

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Wednesday, December 21, 2016
SBP: Incretin drugs may act via more brain pathways than previously thought

GLP-1 agonists (GLP-1RAs) may impact the brain in entirely different ways than was previously thought to promote weight loss. Scientists initially believed that these incretin-based type 2 diabetes drugs only bind to receptors in the hypothalamus but they may in fact affect many more brain circuits. ..

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Friday, November 11, 2016
SBP: How the immune system helps build muscle

Discovery of factor that enhances muscle repair could lead to new therapies for muscle damage ..

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Thursday, November 03, 2016
Major family of gene-regulating proteins has drug-sized pocket

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it’s difficult to design and screen drugs against them. But a new study suggests that a key group of transcription factors are in fact ‘druggable,’ including several that could be targeted to treat cancer, metabolic disease, or autoimmune conditions. ..

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Monday, August 08, 2016
SBP: Scientists discover potential avenue to early treatment for type 2 diabetes

Researchers at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new potential target for drugs to prevent type 2 diabetes. A paper published in the Journal of Clinical Investigation shows that blocking a cellular glucose sensor in muscle improves insulin responsiveness.  ..

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